As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6, and vitamin B12 may reduce the risk of vascular disease. Vitamin B12 and folate are required by the enzyme that converts homocysteine back to methionine. Folate is provided in this formula as Metafolin®, the naturally occurring universally metabolized form of folate. Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. Vitamin B6 is required in each of the two enzymatic reactions that convert homocysteine to cysteine. One of the major roles of betaine, also known as trimethylglycine, is in promoting healthy homocysteine metabolism. It is believed that betaine may be especially supportive when vitamin B12, folic acid and vitamin B6 are not sufficient to maintain healthy homocysteine levels. Vitamin B12 is derived from microbiological fermentation. Vitamin B6 and folic acid (Metafolin®, L-5- MTHF) are synthetically produced. Betaine is originally derived from sugar beet molasses and undergoes an extensive purification process. Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and hypoallergenic plant fiber is derived from pine cellulose. SUGGESTED USAGE As a dietary supplement, take 1 capsule, 2 times daily. INGREDIENTS Serving size: 1 capsule Vitamin B6 25 mg -(as pyridoxal 5' phosphate) (activated B6) Folate (as Metafolin®, L-5-MTHF) 400 mcg Vitamin B12 (as methylcobalamin) 200 mcg Trimethylglycine (anhydrous betaine) 500 mg Other ingredients: vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), ascorbyl palmitate WARNINGS If you are pregnant or lactating, have nay health condition, or are taking any medication, consult your health professional before use. Folic acid-containing supplements may interfere with methotrexate therapy in people with cancer. Keep out of reach of children. Use only if safety seal is intact. ADDITIONAL INFORMATION This formula requires refrigeration after opening.